Resource loading system and method for use in atmosphere-containment scenarios

ABSTRACT

The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The system comprises a cylinder adapted to be received by a region of a containment enclosure forming an aperture so that a hermetic seal exists between the cylinder and the aperture; a canister coaxially positioned within, and in slidable communication with the cylinder such that a hermetic seal exists between the canister and the glove port. The invention also provides a method for transporting material into or out of a containment structure.

CONTRACTUAL ORIGIN OF THE INVENTION

The United States Government has rights in this invention pursuant toContract No DE-AC02-06CH11357 between the United States Government andUChicago Argonne, LLC representing Argonne National Laboratory.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates generally to the field of industrial laboratorysafety and security, and specifically this invention relates to a systemand method for providing rapid change-over for various resource types,and for easily transferring materials in to and out of a confinementsystem without the potential for contaminants or atmospheres crossingthe confinement barrier.

2. Background of Invention

Atmosphere containment systems have various ports for materialtransition and resources across the confinement barrier. Gloveboxes,like other containment systems, facilitate the needs of researchpersonnel in handling and manipulating hazardous materials by separatinga generally uncontaminated exterior area from a contaminated area.Alternatively, containment systems are used inhandling/preparing/packaging sensitive (perhaps purified) materialswithin a clean room enclosure such as a glovebox so as to isolate thematerials from the external environment. The side of the barrier, insideor outside, depends on the use of the confinement system. In “clean”glovebox type applications, as found in the pharmaceutical productionindustry, the glovebox containment prevents contaminants from enteringthe product process area. With hazardous material applications, thebarrier provides protection to workers manipulating the materials.

Gloveboxes surround and control such hazardous materials by physicallyisolating the hazard inside a defined enclosure while permittinghands-on work via glove-ports. Since gloveboxes are designed andfabricated for a specific application, future changes in use, with theassociated need to change/add resources, is very difficult. As a result,it is not uncommon to see gloveboxes “jury-rigged” in labs to get aroundthe permanently-configured design of the glovebox to make it usable forthe required experiment or production process. This jury-rigged resourcechange, driven by necessity, degrades the containment capability of theglovebox and increases the possibility of loss of containment withconsequent problematic effects.

Hazards commonly encountered with traditional glovebox use include, butare not limited to, unmitigated fire propagation inside the glovebox,and hazards specific to a type of technology (e.g., chemical,biological, pharmacological, Engineered Nano Particles, and nuclear).Further, as traditional gloveboxes often lack a convenient method fortransferring hazardous materials to and from the glovebox while theglovebox is in use, users of such gloveboxes must load hazardousmaterials into the glovebox prior to initiating use. This requiresanticipating all of the reagent and tool needs prior to beginning work.Furthermore, replacing, removing and/or otherwise transferring hazardousmaterials in such a glovebox often requires the user to end the usagesession and breach the barrier for the required material transfer orglovebox modification and resource addition such as electrical, data, orprocess fluid additive.

As a result, once glovebox operations begin, users are unable to bringunanticipated yet needed additional materials into the glovebox. Inturn, certain aspects of experimental creativity and complexity may berestricted on part of the user. Further, in traditional gloveboxarrangements, volume within the glovebox must be first allocated to thehousing and storage of a given hazardous contaminant, and also to anyproduct (such as those materials generated via clean room technology)produced. Thus, overall experimental and physical capacity is oftenlimited.

Given the demanding needs of research personnel, traditional gloveboxeslacking a method for transferring contaminant materials during usage arelimiting. Further, general administrative and other methods such asbagging or out-right system breach procedures consume time, energy andresources and may be ineffective and/or inefficient at transferring inhazardous materials into the glovebox or purified substances out of theglovebox as desired. For instance, resources may be wasted during such atransfer resulting in a quality risk of bad product, or compromising theintegrity of the experiment. Moreover, consumption of the wrong resourceduring a transfer may result in further production or experimentaldelays. Also, the proper cleaning of hazardous materials as related tousage with a glovebox may require the user to wear appropriate personalprotective equipment (“PPE”) resulting in an additional inconvenience.Moreover, consumption of the wrong resource during a transfer may resultin further production delays.

Usage of a traditional glovebox lacking an independent means oftransferring in and out hazardous materials limits resources availablefor a given experiment and often does not permit for convenientreal-time process change. Further, resource modification, when needed,can become costly. The challenges, either taken individually or inconjunction, can result in lengthy production delays.

A need exists in the art for a system for transferring substrates,tools, and other matters in and out of containment systems, thosesystems including but not limited to process-, hazard-, andresearch-enclosure systems generally, and gloveboxes, containmentsystems, isolation systems, confinement systems, cleanrooms, negativeair systems, and positive air system areas specifically. The systemshould prevent intermingling of containment environments with regionsoutside of contamination of the environment exterior to the containmentsystem with hazardous materials. Furthermore, the system should operatewith existing containment structures and devices.

SUMMARY OF INVENTION

An object of the present invention is to provide a device and method fortransporting materials and resources in and out of a containment area,such as a glovebox or cleanroom, that overcomes many of thedisadvantages of the prior art.

Another object of the present invention is to provide a device andmethod for transporting materials in and out of a containment system,such as a glovebox while keeping the internal atmosphere of thecontainment system sealed from the external atmosphere. A feature of theinvention is the use of transport modules that are in one-way slideablecommunication with the glovebox, to affect transfer into or out of thecontainment system. An advantage of the invention is that the modulescomprise materials transfer encapsulation means such as a flexiblewebbing, one side of which is in contact with the atmosphere outside thecontainment enclosure while simultaneously another side of the webbingis in contact with the atmosphere inside the containment enclosure. Thisconfiguration assures a substantially complete barrier of atmosphereexchange between the inside of the containment system and the ambientenvironment contacting the exterior of the containment system while themodule is in use.

Still another object of the present invention is to provide a system fortransporting materials in and out of a glovebox. A feature of theinvention is a materials transport module parts of which are in fluidcommunication with the interior atmosphere of the glovebox and otherparts of which are not in fluid communication with the interioratmosphere glovebox. An advantage of the invention is that the gloveboxremains sealed from the external environment during materials transfer,even when more than one module is utilized. This seal is maintained eventhough two modules are utilized at the same time and are in physicalcontact with each other during use.

Yet another object of the invention is providing a method for adding orsubtracting multiple types of resources individually, in groups, orreplacement resources (such as tools, solid materials/reagents/fluidexchange, data ports, electrical outlets, vacuum adapter, or baggingsleeve cartridge) to interior atmospheres of confinement systems such asgloveboxes or clean rooms. A feature of the method is using existingaccess portals of the confinement systems to receive a plurality ofdifferent resource transport vehicles. An advantage of the method isthat new vehicles can be utilized simultaneously with expended vehicleswithout breaching the confinement barrier or compromising the uniquenessor quality of the resource.

Briefly, the invention provides a system for preventing fluid exchangebetween the interior and exterior of a enclosure during materialtransport, the system comprising: a cylinder adapted to be received by aregion of the enclosure forming an aperture so that a hermetic sealexists between the cylinder and the aperture; a canister coaxiallypositioned within, and in slideable communication with the cylinder suchthat a hermetic seal exists between the canister and the enclosure.

Also provided Is a method for transporting material into or out of anenclosure, the method comprising supplying a flexible tube having afirst surface in fluid communication with the internal atmosphere of theenclosure, a second surface not in fluid communication with the internalatmosphere, a first end sealed to a third surface not in fluidcommunication with the internal atmosphere, and a second end sealed uponitself; encapsulating the material with the second surface proximal tothe second end; extending the second of the tube into the internalatmosphere of the enclosure; tying off a portion of the tube so that thematerial is proximal to the second sealed end and the portion of thetube tied off; and cutting the tube between the tied off portion and thesecond sealed end to expose the material to the internal atmosphere.

BRIEF DESCRIPTION OF DRAWINGS

The invention together with the above and other objects and advantageswill be best understood from the following detailed description of thepreferred embodiment of the invention shown in the accompanyingdrawings, wherein:

FIG. 1 is a free space perspective view of the transport modulepositioned for entry into the transport tunnel, in accordance withfeatures of the present invention;

FIG. 2 is an elevational view of one embodiment of the invention;

FIG. 3 is a schematic view of the invented system in use at the start ofa materials transfer process, in accordance with features of the presentinvention; transport tunnel;

FIG. 4 is a schematic view of the invented system in use about midwaythrough a materials transfer process, in accordance with features of thepresent invention;

FIG. 5 is a schematic view of the invented system in use near the end ofa materials transfer process, in accordance with features of the presentinvention;

FIG. 6 is a schematic view of the invented transfer system depicting theaddition of a second materials transport module into a transport tunnelof the system simultaneous with the expulsion of a first materialstransport module from the transport tunnel, in accordance with featuresof the present invention;

FIG. 7 is an exploded perspective view of an embodiment of the system inaccordance with features of the invention;

FIG. 8 is a detailed cut-away perspective view of the invented systemshowing two materials-transport modules nested within a transporttunnel, in accordance with features of the present invention;

FIG. 9 is a perspective view of transport module, in accordance withfeatures of the present invention;

FIG. 10 a top view of transport module and a loading tunnel adapted toreceive the module, in accordance with features of the presentinvention;

FIG. 11 is a view of the transport tunnel being received by a gloveboxwall, and an transport module coaxially aligned with the tunnel, inaccordance with features of the present invention transport tunnel;

FIG. 12 is a cut-away side view of the transport tunnel as inserted intothe attachment sleeve;

FIG. 13 is a front view of an adapter sleeve for use with the inventedtransport method and system, in accordance with features of the presentinvention; and

FIG. 14 is a front view of a multi-port transport module, in accordancewith features of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

The foregoing summary, as well as the following detailed description ofcertain embodiments of the present invention, will be better understoodwhen read in conjunction with the appended drawings.

As used herein, an element or step recited in the singular and precededwith the word “a” or “an” should be understood as not excluding pluralsaid elements or steps, unless such exclusion is explicitly stated.Furthermore, references to “one embodiment” of the present invention arenot intended to be interpreted as excluding the existence of additionalembodiments that also incorporate the recited features. Moreover, unlessexplicitly stated to the contrary, embodiments “comprising” or “having”an element or a plurality of elements having a particular property mayinclude additional such elements not having that property.

The invention provides a system and method for using already existingcontainment systems to optimize material and fluid transfer into and outof controlled atmospheres. In an embodiment of the invention, permanent,standard sized ports, which are found on substantially all gloveboxes,are reversibly retrofitted or otherwise utilized to expedite transfer ofmaterials, fluids, wires for two way electrical signals, power, or datatransfer; piping, vacuum adaptor, plus in some cases integration with anairlock. Transfer can occur both into and out of a glove box using abag-in, bag-out device developed by the inventors.

Turning to the figures, a view of one embodiment of the confinementunidirectional resource loading system 10 is found in FIG. 1. Theloading system 10 comprises several overall elements including amaterials transport module 20 and a materials transport tunnel 24. Thematerials transport tunnel has an opening at each of its two ends and issubstantially continuous so as to have solid sides impervious to fluids.As depicted in FIG. 2, the transport tunnel 24 is adapted to becoaxially and removably received by an aperture 12 which defines atypical glove port 40 formed in vertically disposed walls 66 of standardgloveboxes. The transport module serves as a vehicle for bagging in andbagging out environmentally sensitive reagents, and also serves asvehicle for transporting tools, hardware and other substrates.

In operation, the transport module 20 and transport tunnel 24 arespatially arranged via a longitudinal axis a of the loading system 10.The materials transport module 20, such as a canister, has a first end92 and a second end 94, the module defining a first cross section. Thematerials transport tunnel 24, such as a transport tunnel extendslength-wise into a contaminated interior cavity 64 of a glovebox. Theinterior cavity 64 of the glovebox is separated from an area outside theglovebox by the vertically disposed wall 66 of the glovebox having adefined thickness.

Radially extending protrusions 52 are integrally molded with an exteriorsurface 100 of the materials transport module 20. These protrusions 52provide a means for initial insertion and subsequent movement limitationof the bag canister 20 into the materials transport tunnel 24. The crosssections of each the materials transport module 20 and the materialstransport tunnel 24 are proportionately sized such that the protrusions52 may contact an inner surface of the tunnel 24. In an embodiment ofthe invention, the protrusions are arc shaped defining a concave surfaceand a convex surface. The materials transport module 20 is inserted intothe materials transport tunnel 24 such that the convex surface facestoward the containment structure, such as a glovebox. More generally,the transport module 20 is inserted into the materials transport tunnel24 such that the convex surface faces in the direction in which themodule 20 will travel.

A first end 21 of the materials transport tunnel 24 may terminate in amedially directed lip 78 comprised of reversibly deformable material. Asecond end 23 of the materials transport tunnel terminates in aradially-directed flange 16. The flange facilitates easy entry of thematerials transport module 20 (such as a bag canister described infra)into the transport tunnel 24 in a direction toward the glovebox. Thearc-shaped protrusions 52 compress against a flexible movement limiter26 when advancing toward the glovebox. The limiter 26 prevents atransport module 20 from being pulled backward once inserted into thetunnel 24. The movement limiters 26 comprise reversibly deformableelongated substrate such as spring metal, one end of which is attachedto an inwardly directed surface of the tunnel 24 and the other end ofwhich is unattached and positioned medially from the inwardly directedsurface of the tunnel such that the movement limiter 26 forms an acuteangle β to the inwardly directed surface. The arc-shaped protrusions 52have concave inner sections 104 facing away from the glovebox so as toreversibly interlock with the flexible movement limiter 26 to preventmovement of the bag canister 20 away from the glovebox.

To optimize the interplay between the movement limiter 26 and theprotrusions 52, the circumference of the transport tunnel 24 may befurther constricted via a first tightening clamp, clip or belt 44 and asecond tightening clamp, clip or belt 46 to increase compressive forcebetween the arc-shaped protrusions 52 and the flexible movement limiter26 as needed. Screws 58 thread into set bindings 56 which are affixed onto the tightening belts 44 and 46, respectively. The tightening belts44, 46, (e.g., jubilee clips) extend circumferentially around thetransport tunnel 24 so as to confer a medially-directed compressiveforce upon the tunnel, that force ultimately to be transferred to anymaterials transport module 20 residing in the tunnel.

Upon insertion of the materials transfer module 20 into the transfertunnel 24 and passage through the flexible movement limiter 26, the bagcanister may abut against a medially directed, flexible partition or lip78. An embodiment of the lip comprises a rubber overhang which issubstantially rigid to stymie (but not prevent) continued movement ofthe transport module 20 toward the glovebox without additional forceapplied. In essence, the overhang provides a tactile signal point to theoperator that the end of the tunnel has been reached by the module.

Materials Transport Module Detail

A salient feature of the invention is that the materials transportmodule 20 travels in one direction, which is toward the interior of acontainment structure, such as a clean room or glovebox. The materialstransport module 20 comprises a myriad of configurations, depending onthe material to be shuttled into or out of the glovebox. For example,the materials transport module can comprise an electrical outlet, atransport bagging canister (described below), utilities, USB Data Portinterface, a process gas input, a new glove and any other resource thatthe user needs that can fit within the confinement penetration. Theplacement of the module within the tunnel 24 results physicalconfinement penetration whereby forward portions of the module 20protrude into or make contact with the interior atmosphere of thecontainment while aft portions of the module remain free of contact withthe interior atmosphere. All the while, flexible webbing portions of themodule are capable of making fluid and solid transfers between theinterior and exterior atmospheres.

In an embodiment of the invention, the materials transport module 20defines a housing for stowing an elongated flexible tubular poly sleeve82 comprising reversibly deformable plastic film or other type ofplastic extrusion webbing, the tube (e.g. a bag) having a first end anda second end. The first end of the tube is sealed to or otherwiseattached to a first end 92 of an interior region of the module, thatregion shaped as a longitudinally extending annular space 50. In thisembodiment, the materials transport module 20 is cylindrical in shapeand has a medially extending lip 14 circumscribing a periphery of thebag canister 20, thereby creating a medially disposed, longitudinallyextending portal which is coaxial with the longitudinal axis a of thematerials transport module 20. This portal defines a second crosssection. The lip 14 terminates in approximately a 90 degree bend andextends axially from an exterior perimeter 112 of the first end 92 suchthat the portal comprises a sleeve 15 extending substantially the entirelength of the materials transport module 20. The sleeve 15 terminatesproximal to the second end 94 of the materials transport module 20 so asto define the second cross section. However, unlike the configurationdefining the second cross section at the first end 92 of the module, thesecond cross section at the second end provides a means 98 for accessingthe annular space 50.

As described earlier, the materials transport module 20 (such as a bagcanister) has the circular lip 14 that extends in the inward radialdirection from a perimeter 96 at the end 92 of the bag canister.Similarly, the circular lip 14 extends in the inward radial directionfrom the opposing end 94 of the bag canister 20. Further, thecylindrical interior section 12 extends length-wise through the bagcanister 20 from the circular lip 14 located at the opposing end 94. Thepliable bag 82 may be embedded for storage in an annular space 50located in between the circular lip 14 and the cylindrical interiorsection 12. A user may extract the pliable bag 82 from an open end 98 ofthe sleeve 15, and then thread the bag in the forward direction 80 toenter into the contaminated interior cavity 64 of the glovebox.

FIG. 3-5 illustrates the bag-in bag-out materials transport module 20 inoperation for the bag-in procedure, so called in that materials to betransported into a containment are first bagged externally and thentransported into the containment area. It is noteworthy that the bag-inprocedure can also be employed as a bag-out procedure whereby materialsto be transported out of a containment are first bagged up within thecontainment and then transported out of the containment. FIG. 3 picturesa front surface of the materials transport module 20 as havingprogressed left to right to the end of the transport tunnel 24. At thispoint, the front surface of the materials transport module 20 is inclose spatial relationship to a free end of the flexible rubber seal 78.Any further progression of the materials transport module 20 in an axialdirection toward the interior of the glovebox would result in the modulecontacting the free end of the rubber seal and causing the free end toshift away from the transport tunnel transport tunnel 24 and toward theinterior of the containment interior. (See FIG. 6.)

As shown here, movement of the rubber seal 78 creates an opening such asan iris defined by the unattached portions of the rubber seal 78permitting the second end of the flexible tube noted supra, anddesignated herein as 82 to be pushed through the iris or opening definedby the unattached portions of the rubber seal so as to enter into theinterior 64 of the glovebox.

As noted supra, the pliable bag 82 is stored within the annular space 50of the transport module, the bag's open end sealed to an interior regionproximal to the first end 92 end of the module 20. Operation of abag-in/bag-out materials transport module, comprises placing a reagent,substrate, tool or other object 84 inside the pliable bag 82 (heretoforestowed in the annual space 50, said placement preferably occurring priorto the bag 82 being drawn through the opening created by the movement ofthe flexible rubber seal 78.

Possible methods of pulling the bag 82 through said gap includemanipulation by the user inside the glovebox. For example, a user mayinsert a hand into a glove in a glove-port located adjacent to theloading system 10. Next, the user may take the hand in the glove tofurther extract the pliable bag 82, as needed, from its semi-deployedposition as shown in FIG. 3. Once an item intended for transport isplaced in the bag, the bag is tied off 88 so as to isolate the item fromthe environment exterior to the glovebox interior. Further, uponreaching the bottom of the bag such that no further bag length remainswithin the annual space, the materials transport module 20 (in this casethe bag canister) may be replaced with a second materials transportmodule 20B (See FIG. 6) such that the second materials transport module20B is inserted into the materials transport tunnel 24 so as to push thefirst materials transport module 20 completely through the tunnel andinto the interior space of the glovebox.

FIG. 4 next shows a rotational motion 86 being applied to the pliablebag 82 thereby causing a length of the bag to twist upon itself. Thistwisted portion can be secured by a tie 88 or other device so as toeliminate any fluid communication between the object 84 and the outsideatmosphere (i.e., the atmosphere that is outside the interior of theglovebox). As depicted in FIG. 5, the user finally delivers the objectto the contaminated interior cavity 64 of the glovebox by clipping thatportion 90 of the bag distal from the tie off 88. As described earlier,a user may manipulate the pliable bag 82 by using a hand in a glove inthe glovebox.

The materials transport module 20 may be designed to hold several feetor meters of plastic webbing which can be twisted off along itslongitudinal axis as needed to transport materials in or out of theglovebox. Once the length of the pliable bag 82 is expended, the bagcanister 20 is deemed spent.

As discussed supra, a second materials transport module 20B with anotherlength of plastic webbing (or carrying some other item) may then beinserted into the transport tunnel 24 to press against the spentmaterials transport module 20, as shown in FIG. 6. The second materialstransport module 20B may contact the spent bag module 20, forcing it toadvance toward the interior of the glovebox, forcing it to open and pushthrough the flexible rubber seal 78, and to finally forcing it to fallinto the contaminated interior cavity 64 of the glovebox. The firstmaterials transport module can fall to the floor of the containmentinterior via gravity, centrifugal force, or some other means. Forexample, a user can grab the forward end of the module and pull theremainder of the module out of the tunnel so as to set it aside in acontrolled fashion to prevent tipping of reagent or product containersor damage of equipment or glassware within the containment area.

The confinement unidirectional resource loading system 10 is designed toallow trained personnel to rapidly complete the entire bag canister 20replacement procedure as described with no special tools, and withoutthe need to wear any protective apparel.

FIG. 7 shows an exploded view of the confinement unidirectional resourceloading system 10 as comprising several concentric cylindricalcomponents including a plurality of materials transport modules 20coaxially aligned with the transport tunnel materials transport tunnel24.

The transport modules 20 depicted in FIG. 7 show a plurality of radiallyprojecting ridges 52 from an exterior surface 100 of the modules so asto be substantially completely circumscribing the periphery of themodules. In an embodiment of the invention, the ridges are arc-shapedand extend in a perpendicular orientation from the exterior surface 100of the transport module 20. As depicted in FIG. 2, these arc-shapedprotrusions 52 have a concave inner section 104 that faces away from theglovebox when the system is installed and a convex surface 106 thatfaces toward the glovebox when the module is installed in the materialstransport tunnel 24.

Upon insertion and movement of the bag canister 20 through the transporttunnel 24 transport tunnel the concave surface 104 of arc-shapedprotrusion 52 reversibly interlocks with flexible movement limiters 26to prevent movement of the module 20 in the direction opposite to theforward motion of the transport module 20. Generally, the protrusions 52also serve as a means to prevent yawing or deflection from thelongitudinal axis a of the transport module 20 with the longitudinalaxis of the materials transport tunnel 24. Such deflection may otherwiseresult in atmosphere exchange between the inside and the outside of theglovebox. In addition, the protrusions 52 may comprise a semi-rigidmaterial so as to serve as gaskets between the transport module 20 andthe tunnel 24, thereby providing additional means to prevent fluidcommunication between the interior of a containment structure and theexterior environment/atmosphere.

Transport Tunnel Detail

The transport tunnel 24 rotatably interlocks with an attachment sleeve34, the later of which is removably fastened to a portion of thecontainment structure via an O-ring 38 mated with a groove 42circumscribing the existing glovebox port 40. The transport tunnel 24has an interior surface 102 and an exterior surface 32. A radiallyextending lip or ridge 30 is located on the exterior surface 32 of thetransport tunnel 24. The stabilization ridge 30 protrudescircumferentially around the exterior surface 32 and provides a sealingedge with a first circumferential periphery 48 of the attachment sleeve34. Sealing occurs when the transport tunnel 32 is slidably received bythe attachment sleeve 34.

An exterior surface of the attachment sleeve 34 defines acircumferentially extending ridge 36 that is adapted to be received bycomplementary shaped groove 42 located on an existing glove-port 40.Typically, the glove-port 40 is mounted on the interface wall 66 (notpictured). A compressible gasket seal 38 is positioned intermediate theridge 36 and the groove 42 upon complete assembly of the loading system10.

FIG. 8 illustrates a close-up cut away of the loading system 10featuring two coaxially aligned materials transport modules designed tostore plastic webbing substrate as discussed supra. The pliable bag 82(not pictured) may be stored in the vacant storage area 50 and extractedby a user through the gap 98 when necessary for use. It should be notedthat while FIG. 8 depicts a configuration for bagging-in scenarios, theconfiguration can be used when material is to be transported OUT ofcontainment structures, such as gloveboxes. Also, the configuration canbe reversed for bagging-out operations, such that modules travel awayfrom clean room containment structures to be collected outside of saidclean containment enclosures.

The arc-shaped protrusions 52 (which can also serve as gaskets) extendfrom the exterior surface 100 of the bag canister 20 and have concaveinner sections 104 that face away from the glovebox when the system isinstalled. The flexible movement limiter 26 is attached to a mediallyfacing surface of the materials transport module 24 so as to extendinwardly toward the radially facing surface of the transport module. Thearc-shaped protrusions 52 reversibly interlock with the flexiblemovement limiter 26 to prevent movement of the bag canister 20 in thedirection away from the containment enclosure (for example a glovebox inbagging in scenarios). The dashed arrow 80 depicts the direction of themodules.

As shown here, the materials transport module 20 slideably inserts intothe transport tunnel 24 to and contacts a spent materials transportmodule 20 during routine bag canister 20 replacement procedures.Ideally, this procedure occurs while the spent canister still maintainsa seal between the inside of the glovebox and the exterior of theglovebox. Only when the replenishment module is in place does thefollowing operation proceed: Movement of the replenishing module 20 inthe forward direction 80 causes the bag canister 20 to contact and abutagainst the spent bag canister to force the spent bag canister throughthe flexible rubber seal 78 (not pictured in FIG. 8). The spent bagcanister then travels through an opening 118 (not pictured) enlarged byoutward movement of the flexible rubber seal to enter into thecontaminated interior cavity 64.

The transport tunnel 24 features a guidance brim integrally molded withthe radially directed flange. The guidance brim 28 may function to guidethe bag canister 20 to slideably enter into the interior of thetransport tunnel 24, particularly when a user of the system needs toquickly insert a replacement materials transport module 20 into thetunnel 24.

The attachment sleeve 34 featuring the aforementioned medially facinggroove 48 is held firmly in place against the transport tunnel 24 by afirst tightening belt 44 and a second tightening belt 46, such asjubilee clamps. Both tightening belts, 44 and 46, are placed around thecircumference of the attachment sleeve 34 and may be tightened viarotation of the screws 58 threaded into set bindings 56.

FIG. 9 illustrates another embodiment of the bag in bag out transportmodule 20.

Flat ridges 110 circumferentially surround an exterior surface 124 ofthe bag canister 20 to compress against the flexible movement limiter 26(not pictured) upon insertion of the bag canister 20 into the transporttunnel 24 (not pictured). The sequential positioning of the flat ridges110 prevents against unwanted movement of the bag canister 20 in theaxial direction 122 opposite to the forward direction 80. However,unlike the arc-shaped protrusions 52 found in the embodiments presentedearlier, the flat ridges 110 are non-curved (e.g., straight) and thus donot have a concave interior section facing away from the forwarddirection 80. This configuration provides stability for the sealinggasket/ring, stability of the canister within the transport tunnel, andforces proper selection and alignment of the sealing gasket/ring. Asidefrom providing proper alignment, these flat, non-arched ridges alsointeract with the tips of the movement limiter 26 to facilitate forwardonly movement of the modules 20.

The bag canister 20 as shown in FIG. 9 may be constructed of a rigidplastic material such as, but not limited to, poly-vinyl chloride(“PVC”). Alternatively, the bag canister may be of metal construction.

FIG. 10 shows a top view of the embodiment of the transport module 20first shown in FIG. 9 placed alongside an embodiment of the transporttunnel 24. As shown in FIG. 10, the bag canister 20 comprises a doublewalled cylinder defining an annular space 50 there between adapted toslideably communicate with a plastic bag 82.

FIGS. 9 and 10 show the transport module 20 having sequential ridges 110circumferentially surrounding the exterior surface 124. The module 20,as shown here, slideably inserts into the transport tunnel 24 where theridges 110 reversibly interlock with the flexible movement limiter 26(not pictured) to prevent against unwanted longitudinally directedmovement of the bag canister 20 in the direction opposite to the forwarddirection 80.

FIG. 11 shows the loading system 10 as securely mounted on the interfacewall 66. The transport module 20 slideably inserts into the transporttunnel 24 which affixes to the attachment sleeve 34. The attachmentsleeve 34 mounts onto the glove-port 40 mounted on the interface wall66. Adjacent glove-ports 62 permit the user to insert a hand into aglove in the adjacent glove-port 62 to extract the pliable bag 82 (notpictured) from inside the loading system 10 to enter the contaminatedinterior cavity 64 of the glovebox.

FIG. 12 shows a side cut-away view of the loading system 10 includingthe second transport module 20B inserted in the forward direction 80into the transport tunnel 24 to press against the materials transportmodule 20 (such as a spent bag canister). The spent module 20 depletedof the pliable bag 82, in turn, pushes open the flexible rubber seal 78to depart the transport tunnel 24 and fall into the contaminatedinterior cavity 64 of the glovebox (not pictured). However, until hespent module is fully detached from the medially facing walls of thetunnel, a hermetic seal exists between the first module 20 and thesecond module 20B.

Ridges 52 may both be curved or flat, depending on the embodimentchosen, and circumferentially surround an exterior surface 100 of thebag canister 20. The ridges 52 may be made from a rigid material,similar or identical to that selected for construction of the bagcanister 20 or any of the other mentioned components. Accordingly, theridges 52 do not reversibly deform upon insertion into the bag canister20. The bag canister 20 may be sized such that the ridges 52 contact theinterior surface (i.e., the medially facing surface) 102 of thetransport tunnel 24 upon insertion of the bag canister 20 into thetransport tunnel 24. The ridges 52 remain in contact with the interiorsurface 102 of the transport tunnel 24 as the bag canister 20 moves inthe forward direction 80 to press against the flexible movement limiter26. To facilitate sealing and easier sliding, silicone or similarlubricant or grease may be employed to convex surfaces of the ridges incontact with the interior surfaces 102 of the tunnel.

The flexible movement limiter 26 extends from the interior surface 102at an initial angle 128. The flexible movement limiter 26 flattens inresponse to downward pressure exerted by convex regions of the ridge 52passing over it. Accordingly, the angle 128 reduces relative to theposition of the ridge 52 over the flexible movement limiter. Uponcomplete passage of the ridge 52 over the flexible movement limiter 26,the flexible movement limiter 26 may spring back into its originalposition at an initial angle 128, i.e., to its medially-biased position.

FIG. 13 is a front view of an adapter for use in glove ports (or otheraccess ways having larger than standard diameters. For example, whilethe above-described materials transport modules 20 can be any size,preferably, the diameters of the modules are dimensioned so as to bereceived by standard sized glove box ports. For larger sized gloveboxports (e.g., 10 inches in diameter) an adapter cartridge 25 is utilized,of the same general shape and function as the transport module, which isto say, the adapter cartridge has the same peripheral sealing meansalong it periphery as does the afore-described transport module 20.Similarly the medially facing circumferentially extending surface 27 ofthe adaptor cartridge has similar structure to that described for thesimilarly disposed surface of the transport tunnel 24. The surface 27defines a diameter complementary to the cross section of modules morecommonly used. Specifically, a 10″ to 8″ diameter reducing cartridgeallows an 8 inch diameter transport module 20 to be slidably received bythe adaptor cartridge 25 and maintain the separation of atmospheresoutlined supra in instances where standard 8 inch glove ports areretrofitted.

FIG. 14 is a front view of a multi-port materials transport module 29.In this embodiment, a plurality of ports of ingress and egress to andfrom the containment atmosphere are provided in one module. Theinteraction between the peripheries of each of these smaller ports andcomplementarily shaped miniaturized transport cartridges 31 mimics theinteraction in form and function described between the standardmaterials transport module 20 and tunnel 24 described supra. A salientfeature of this multi-port transport module is that each of theminiaturized transport cartridges 31 can be pushed through the transportmodule 29 independent of the positioning of the remaining miniaturizedtransport cartridges. In addition, all miniaturized cartridges canadvance simultaneously when the multi-port materials transport module 29is advanced. Further, each of the miniaturized transport modules 31 canbe actuated independently of advancement of the multi-port materialstransport module 29 through the tunnel 24.

It is to be understood that the above description is intended to beillustrative, and not restrictive. For example, the above-describedembodiments (and/or aspects thereof) may be used in combination witheach other. In addition, many modifications may be made to adapt aparticular situation or material to the teachings of the inventionwithout departing from its scope. While the dimensions and types ofmaterials described herein are intended to define the parameters of theinvention, they are by no means limiting, but are instead exemplaryembodiments. Many other embodiments will be apparent to those of skillin the art upon reviewing the above description. The scope of theinvention should, therefore, be determined with reference to theappended claims, along with the full scope of equivalents to which suchclaims are entitled. In the appended claims, the terms “including” and“in which” are used as the plain-English equivalents of the terms“comprising” and “wherein.” Moreover, in the following claims, the terms“first,” “second,” and “third,” are used merely as labels, and are notintended to impose numerical requirements on their objects. Further, thelimitations of the following claims are not written inmeans-plus-function format and are not intended to be interpreted basedon 35 U.S.C. §112, sixth paragraph, unless and until such claimlimitations expressly use the phrase “means for” followed by a statementof function void of further structure.

As will be understood by one skilled in the art, for any and allpurposes, particularly in terms of providing a written description, allranges disclosed herein also encompass any and all possible subrangesand combinations of subranges thereof. Any listed range can be easilyrecognized as sufficiently describing and enabling the same range beingbroken down into at least equal halves, thirds, quarters, fifths,tenths, etc. As a non-limiting example, each range discussed herein canbe readily broken down into a lower third, middle third and upper third,etc. As will also be understood by one skilled in the art all languagesuch as “up to,” “at least,” “greater than,” “less than,” “more than”and the like include the number recited and refer to ranges which can besubsequently broken down into subranges as discussed above. In the samemanner, all ratios disclosed herein also include all subratios fallingwithin the broader ratio.

One skilled in the art will also readily recognize that where membersare grouped together in a common manner, such as in a Markush group, thepresent invention encompasses not only the entire group listed as awhole, but each member of the group individually and all possiblesubgroups of the main group. Accordingly, for all purposes, the presentinvention encompasses not only the main group, but also the main groupabsent one or more of the group members. The present invention alsoenvisages the explicit exclusion of one or more of any of the groupmembers in the claimed invention.

The embodiment of the invention in which an exclusive property orprivilege is claimed is defined as follows:
 1. A system for preventingfluid exchange between the interior and exterior of a containmentenclosure during material transport, the system comprising: a. acylinder adapted to be received by a region of the enclosure forming anaperture so that a hermetic seal exists between the cylinder and theaperture; and b. a canister coaxially positioned within, and in slidablecommunication with the cylinder such that a hermetic seal exists betweenthe canister and the enclosure.
 2. The system as recited in claim 1wherein the canister slides in the cylinder in only one direction. 3.The system of claim 1 wherein an exterior surface of the canisterdefines radially extending protuberances having a first surface facingthe interior of the containment enclosure and a second surface facingaway from the containment enclosure and wherein a medially facingsurface of the tunnel supports a plurality of spring clips, each of saidclips comprising a first end attached to the medially facing surface anda second free end adapted to be received by the second surface of theprotuberance.
 4. The system as recited in claim 3 wherein the springclip received by the second surface prevents the canister from slidingaway from the containment enclosure.
 5. The system as recited in claim1, wherein the canister has a plurality of gaskets circumscribing itsperiphery.
 6. The system as recited in claim 1 wherein a plurality ofcanisters are simultaneously accommodated by the cylinder.
 7. The systemas recited in claim 6 wherein an airlock is formed between each of thecanisters.
 8. The system as recited in claim 1 wherein the canisterdefines a central aperture and an annular space circumscribing theaperture.
 9. The system as recited in claim 8 further comprising aflexible extruded webbing defining a tube having a first end attached tothe inside of the annular space and a second end extending into thecentral aperture.
 10. The system as recited in claim 9 wherein the tubeis adapted to receive substrates selected from the group consisting oftools, reagents, electronic componentry, equipment adaptors, andcombinations thereof.
 11. The system as recited in claim 1 wherein thecanister is a multi-port canister defining a plurality of aperturesadapted to slidably receive a plurality of smaller canisters, whereby ahermetic seal is maintained between the smaller canisters and thecanister.
 12. The system as recited in claim 11 wherein a plurality ofmulti-port canisters are simultaneously accommodated by the cylinder andone of the smaller canisters of a first multi-port canister is coaxiallyaligned with one of the smaller canisters of a second multi-portcanister.
 13. A method for transporting material into or out of acontainment enclosure, the method comprising: a) supplying a flexibletube having a first surface in fluid communication with the internalatmosphere of the containment enclosure, a second surface not in fluidcommunication with the internal atmosphere, a first end sealed to athird surface not in fluid communication with the internal atmosphere,and a second end sealed upon itself; b) encapsulating the material withthe second surface proximal to the second end; c) extending the secondend of the tube into the internal atmosphere of the containmentenclosure; d) tying off a portion of the tube so that the material isbetween the second sealed end and the portion of the tube tied off; ande) cutting the tube between the tied off portion and the second sealedend to expose the material to the internal atmosphere.
 14. The method asrecited in claim 13 wherein the third surface is in slidablecommunication with the containment enclosure.
 15. The method as recitedin claim 14 wherein the third surface maintains a hermetic seal with thecontainment enclosure.
 16. The method as recited in claim 13 wherein thetube is adapted to receive substrates selected from the group consistingof tools, reagents, fluid canisters, aggregate material, electroniccomponentry, and combinations thereof.
 17. The method as recited inclaim 16 wherein the substrates are moved between the internalatmosphere and an atmosphere external from the containment enclosure.18. The method as recited in claim 13 wherein the step of encapsulatingthe material comprises hermetically sealing the material within thetube.
 19. The method as recited in claim 13 wherein the second surfaceis in fluid communication with an atmosphere surrounding an exterior ofthe enclosure.